Sex-dependent influence of LMAN1 on lung function and allergen-induced airway hyperresponsiveness

Abstract We recently reported LMAN1 as a regulatory receptor capable of downregulating NF-kB signaling in response to house dust mite (HDM) vitro. In this follow up work, we have subjected WT and KO mice HDM model allergic airway inflammation assessed lung function hyperreactivity (AHR). Given our previous vitro findings, had expected worsened disease the absence LMAN1. Interestingly, when were stratified by sex, observed that while female, HDM-treated exhibited signs enhanced narrowing closure AHR compared their counterparts, male, showed opposite trend. These sex-dependent effects appeared be localized peripheral airways. additionally characterized type extent immune cell infiltration into highlight those features which might account for gender-biased on setting asthma.